| Adopt-a-Sis | Ambassadors & Premier Ambassadors | Art Club |
| Big Sis Little Sis | Book Club | Class Activities |
| Class Officer Positions | Community Service Program | Drug Free Clubs of America |
| French Club | Freshman Council | Fun In Fitness |
| Girls' Athletic Association (GAA) | Girls Who Code | Grace Group |
| Latin Club | MND Academic Team (Greater Cincinnati Academic League) | MND Cougar Dance Team |
| MND Theatre (MNDT) | Model United Nations (MNDMUN) | Moeller Cheerleading |
| Mu Alpha Theta (Mathematics Honor Society) | Multicultural Student Union | National French Honor Society |
| National Honor Society (NHS) | Parish Partners | Respect For Life Club |
| Rho Kappa (Social Studies Honor Society) | Science Club | Spanish Club and Spanish Honor Society |
| Student Government | St. Vincent de Paul Conference | Theatre Club |
| TSA Teams Competition | Worship Commission | Writers' Cafe |
